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KMID : 0869619860030020033
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Journal of Korean Society of Hospital Pharmacists
1986 Volume.3 No. 2 p.33 ~ p.36
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Comparison of the Parmacokinetics of single Dose Gentamicin Administered via Bolus and Ⅳ Infusion
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Charles D. Sands
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Abstract
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Gentamicin was administered in a single dose of 1㎎/㎏ to a healthy adult on two separate occasions; one time by I. V. bolus and the other by a 30 minute I. V. infusion. Serial blood samples were collected for 24 hours and various pharmacokinetic parameters calculated and compared. Gentamicin pharmacokinetics were best described by a three compartment model. Elimination half-life, Vd, AUC and time to peak concentration were similar for the two systems, but peak serum concentration was significantly different. The method of drug administration can have a profound influence on peak serum concentrations and time to attain peak. proper recommendations to obtain blood samples can be made only with the knowledge of drug pharmacokinetics and infusion method used in a specific institution.
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KEYWORD
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